Antibiotic nanoparticles attack respiratory infection at source, reduce drug side effects

Treating respiratory disease is often difficult because drugs have to cross biological barriers such as respiratory tissue and mucosa, and must therefore be given in large quantities in order for an effective amount to reach the target. Now researchers have shown that the use of nanoparticles to carry antibiotics across biological barriers can be effective in treating lung infections. Doing so allows better delivery of the drug to the site of infection, and hence prevents the development of antibiotic resistance which may be caused by too large and continued doses of antibiotic. Additionally, such a strategy might help to overcome the rapid metabolism and excretion of the antibiotic from the body, which happens when it is administered by traditional routes, either orally or intravenously.