Using flexible microparticles as drug carriers to shuttle nanoparticles to the vascular wall

Drug carriers that target the vascular endothelium must adhere to the endothelial vessel wall to achieve clinical stability. The particle size is a critical physical property to prescribe particle margination within biological blood flows and those conducted in-lab. While microparticles are optimal for margination, nanoparticles are better for intracellular delivery. In a new report now on Science Advances, Margaret B. Fish and a research team in chemical engineering, pharmacology and cardiovascular medicine and engineering at the University of Michigan, Ann Arbor U.S., tested flexible hydrogel particles as carriers to transport nanoparticles to a diseased vascular wall. Based on the microparticle modulus, nanoparticle-loaded poly (ethylene glycol)-based hydrogel microparticles delivered more than 50-nm nanoparticles to the vessel wall, when compared to freely injected nanoparticles to achieve more than 3000 percent increase in delivery. The work showed the benefit of optimizing the efficiency margination of microparticles to enhance transport of nanocarriers to the vascular wall. Continue reading at Physorg